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The study demonstrates that blood vessel permeability changes are required for anti-heart antibodies to localize in heart tissue and induce Aschoff body-type granulomatous lesions in animal models.
Granulomatous cardiac lesion of Aschoff body type was produced in rabbits which had been hyperimmunized with duck γ‐globulin followed by an injection of anti‐rabbit‐heart duck antibody. Normal rabbits injected with the same anti‐heart antibody did not show any tissue damage. The localization of anti‐heart antibody was studied by fluorescent antibody technique: In hyperimmunized rabbits myocardial and sarcolemmal localization of duck γ‐globulin was detected, whereas no heart localization of duck γ‐globulin was found in normal rabbit. These results indicate that the permeability change of blood vessels is essential to provide the direct reaction of anti‐heart antibody and heart tissue. Similar studies were performed in rats using rabbit anti‐rat‐heart antibody with comparable results. Although quantitative methods to assay anti‐heart antibody in vitro and in vivo were developed by using radioactive antibody, the quantitative relationship between antibody amount and tissue lesion could not be established.
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Hisao Tomioka (1970) studied this question.
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