Key result
POTS is linked to baroreflex impairment during standing despite preserved cerebrovascular autoregulation versus controls.
Why the study?
The study aims to characterize cardiovascular and cerebrovascular controls in postural orthostatic tachycardia syndrome subjects experiencing exaggerated sympathetic response during orthostatic challenge via unconditional transfer entropy and transfer entropy conditioned on respiratory activity.
Does postural orthostatic tachycardia syndrome (POTS) impair cardiovascular and cerebrovascular control mechanisms during orthostatic challenge compared to healthy controls?
Case-Control (n=33)
No
Does postural orthostatic tachycardia syndrome (POTS) impair cardiovascular and cerebrovascular control mechanisms during orthostatic challenge compared to healthy controls?
Transfer entropy analysis reveals that POTS patients have impaired baroreflex control but preserved cerebral autoregulation during orthostatic stress.
Answers are grounded in this paper and cite their sources.
Baroreflex impairment may inform POTS orthostatic evaluation; hypothesis-generating for respiratory-conditioned transfer entropy before prospective validation.
Objective. Closed loop cardiovascular (CV) and cerebrovascular (CBV) variability interactions are assessed via transfer entropy (TE) from systolic arterial pressure (SAP) to heart period (HP) and vice versa and from mean arterial pressure (MAP) to mean cerebral blood velocity (MCBv) and vice versa. This analysis is exploited to assess the efficiency of baroreflex and cerebral autoregulation. This study aims at characterizing CV and CBV controls in postural orthostatic tachycardiac syndrome (POTS) subjects experiencing exaggerated sympathetic response during orthostatic challenge via unconditional TE and TE conditioned on respiratory activity ( R ). Approach. In 18 healthy controls (age: 28 ± 13 yrs; 5 males, 13 females) and 15 POTS individuals (age: 29 ± 11 yrs; 3 males, 12 females) we acquired beat-to-beat variability of HP, SAP, MAP and MCBv and two R signals, namely respiratory chest movement (RCM) and capnogram (CAP). Recordings were made at sitting rest and during active standing (STAND). TE was computed via vector autoregressive approach. Main results. We found that: (i) when assessing CV interactions, the increase of the TE from SAP to HP during STAND, indicating baroreflex activation, is detected solely when conditioning on RCM; (ii) when assessing CBV interactions, the impact of R on the TE computation is negligible; (iii) POTS shows baroreflex impairment during STAND; (iv) POTS exhibits a normal CBV response to STAND. Significance. TE is useful for detecting the impairment of specific regulatory mechanisms in POTS. Moreover, using different R signals highlights the sensitivity of CV and CBV controls to specific R aspects.
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Gelpi et al. (2023) conducted a case-control in Postural orthostatic tachycardia syndrome (POTS) (n=33). Postural orthostatic tachycardia syndrome (POTS) vs. Healthy controls was evaluated on Cardiovascular and cerebrovascular variability interactions assessed via transfer entropy (TE). Postural orthostatic tachycardia syndrome (POTS) was associated with baroreflex impairment during active standing, while exhibiting a normal cerebrovascular response compared to healthy controls.
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