Why the study?
Existing computational models of the baroreflex do not explicitly incorporate the intrinsic cardiac nervous system, which mediates central control of heart function.
This computational model provides a framework for evaluating bioelectronic interventions like VNS by demonstrating that differential activation of vagal afferents and efferents is required to match in vivo cardiovascular responses.
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Highlights differential vagal activation for HR control in models; leaves open applicability to clinical bioelectronic therapies.
The baroreflex is a multi-input, multi-output control physiological system that regulates blood pressure by modulating nerve activity between the brainstem and the heart. Existing computational models of the baroreflex do not explictly incorporate the intrinsic cardiac nervous system (ICN), which mediates central control of the heart function. We developed a computational model of closed-loop cardiovascular control by integrating a network representation of the ICN within central control reflex circuits. We examined central and local contributions to the control of heart rate, ventricular functions, and respiratory sinus arrhythmia (RSA). Our simulations match the experimentally observed relationship between RSA and lung tidal volume. Our simulations predicted the relative contributions of the sensory and the motor neuron pathways to the experimentally observed changes in the heart rate. Our closed-loop cardiovascular control model is primed for evaluating bioelectronic interventions to treat heart failure and renormalize cardiovascular physiology.
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Gee et al. (2023) studied Cardiovascular control (computational model). Vagal nerve stimulation (computational simulation) vs. Equal stimulation of efferents and afferents / baseline was evaluated on Heart rate and respiratory sinus arrhythmia (RSA) amplitude changes.
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