Key result
Acute pain from physical trauma in an elderly person increased the maximum rate of arterial blood pressure pulse growth (VmaxPP) from 625 ± 74 to 2117 ± 173 mm Hg/s.
Case Report (n=1)
Arterial piezopulsometry demonstrated a significant stress-induced increase in myocardial contractility and altered autonomic regulation in an elderly patient following physical trauma.
Answers are grounded in this paper and cite their sources.
Alerts clinicians to potential pain effects on contractility markers in elderly trauma; case report leaves open prospective validation.
The results of the application of a new method of arterial piezopulsometry for noninvasive assessment of the functional state and physiological mechanisms of autonomous regulation of the cardiovascular system (CVS) in an elderly person with acute pain associated with unexpected physical trauma are described. Such exposure caused a negative stress response in the muscle effectors (MEs) of CVS on the first day, provoking an abnormal increase and acceleration of LV myocardial contractility. Analysis of the arterial blood pressure pulse (PP) wave graphs shows that the maximum rate of PP growth, VmaxPP, reflecting the myocardial contractility, increased from 625 ± 74 before the trauma to 2117 ± 173 mm Hg/s after the trauma, distorting the waveform of the normal graph. The cause of this increase could be the rapid total effect of transmitters of the neuroendocrine sympathoadrenal system on the adrenergic receptors (ARs) of cardiomyocytes (CMs). The results of the spectral analysis of the variability of the PP wave parameters confirm this possibility. It is shown that under stress, norepinephrine from activated sympathetic efferents is added to the already increased content of humoral catecholamines in the extracellular environment of the myocardium near ARs of CMs, which is typical for older people. At the same time, the activity of parasympathetic efferents that release acetylcholine, which inhibits the contractile reaction of the myocardium and, thereby, performs a restraining cardioprotective function, significantly increases. A personalized approach was used to study the mechanisms of autonomous regulation of CVS MEs under stress.
No takes yet. Share an insight, caveat, or question.
Нестеров et al. (2022) conducted a case report in Acute pain associated with unexpected physical trauma (n=1). Acute pain associated with unexpected physical trauma vs. Before trauma was evaluated on Maximum rate of arterial blood pressure pulse growth (VmaxPP). Acute pain from physical trauma in an elderly person increased the maximum rate of arterial blood pressure pulse growth (VmaxPP) from 625 ± 74 to 2117 ± 173 mm Hg/s.
Synapse has enriched 10 related papers. Consider them for comparative context: