Key result
HFE gene mutations C282Y and H63D were significantly associated with an increased risk of type 2 diabetes, with the C282Y GA genotype yielding an odds ratio of 3.01.
Why the study?
Are HFE mutations C282Y and H63D associated with type 2 diabetes and its complications in an Iranian population?
Case-Control (n=290)
Single-blind
No
Are HFE mutations C282Y and H63D associated with type 2 diabetes and its complications in an Iranian population?
Odds Ratio: 3.01 (95% CI 1.87–4.9)
Absolute Event Rate: 67% vs 40%
p-value: p=<0.001
HFE gene mutations C282Y and H63D are significantly associated with the risk of type 2 diabetes and nephropathy in the Iranian population.
Supports replication in Iranian cohorts; leaves open whether HFE genotyping should influence T2D risk assessment or management.
Background: Type 2 diabetes (T2D) is a common metabolic disease caused by insulin secretion defects, which is associated with a variety of complications such as retinopathy, nephropathy, and neuropathy. Objectives: Regarding the relationship between type 2 diabetes and hereditary chromatists, we conducted a genetic analysis on two previously reported mutations C282Y and H63D related to the HFE gene in our population. Patients and Methods: Altogether, 145 patients with type 2 diabetes and 145 healthy controls were examined. A genotyping assay performed using electrophoresis of the DNA digestion products from MboI and RsaI for H63D and C282Y, respectively. Results: Results showed a significant difference between case and controls regarding C282Y (P value < 0.001) and H63D genotypes (P value = 0.013). We also found a relationship between both mutations and nephropathy. Moreover, the difference between C282Y genotypes of patients with retinopathy and healthy controls were statistically significant (P value = 0.020) while there was no association between H63D and retinopathy. In addition, observed differences of both mutations were significant when nephropathic patients compared to the controls. Conclusions: Our study showed a significant association between H63D and C282Y mutations and the risk of type 2 diabetes in Iranian population.
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Golchin et al. (2015) conducted a case-control in Type 2 Diabetes (n=290). HFE mutations C282Y and H63D vs. Healthy controls was evaluated on Presence of C282Y GA genotype (OR 3.01, 95% CI 1.87-4.90, p=<0.001). HFE gene mutations C282Y and H63D were significantly associated with an increased risk of type 2 diabetes, with the C282Y GA genotype yielding an odds ratio of 3.01.
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