What is the clinical evidence from this study?

Study design: Other. Intervention: Lower body negative pressure (LBNP) and dynamic exercise vs. Rest and exercise alone. Primary outcome: Maximal gain for carotid baroreflex control of heart rate (p=<0.05).

What question did this study set out to answer?

To measure maximal carotid baroreflex gain for heart rate and mean arterial pressure control during dynamic exercise combined with cardiopulmonary baroreceptor unloading.

April 1, 1995AJP Heart and Circulatory Physiology

Cardiopulmonary baroreceptors modulate carotid baroreflex control of heart rate during dynamic exercise in humans

Q: What are the key findings of this study?

Exercise combined with lower body negative pressure resulted in reflex heart rate gains (-0.83 beats/min/mmHg) significantly greater than the sum of gains during exercise and LBNP alone (P<0.05).

Q: What question did this study set out to answer?

To measure maximal carotid baroreflex gain for heart rate and mean arterial pressure control during dynamic exercise combined with cardiopulmonary baroreceptor unloading.

View Full Paper

Ask AI

Bookmark

Key result

Exercise combined with lower body negative pressure resulted in reflex heart rate gains (-0.83 beats/min/mmHg) significantly greater than the sum of gains during exercise and LBNP alone (P<0.05).

Why the study?

Does cardiopulmonary baroreceptor unloading modulate carotid baroreflex control of heart rate during dynamic exercise in humans?

Population

Humans

Comparison

Dynamic exercise accompanied by two levels of… vs Rest with and without LBNP, and exercise alone

Design

Other

Authors

JPJ. T. PottsBayer (United States)XSXiangrong ShiUniversity of North Texas PRP. B. RavenUniversity of North Texas

Discussion

Member takes

Implication

May modulate baroreflex HR control with volume shifts during exercise; leaves open clinical translation.

Key Points

To measure maximal carotid baroreflex gain for heart rate and mean arterial pressure control during dynamic exercise combined with cardiopulmonary baroreceptor unloading.
Applied low- and high-level lower body negative pressure (LBNP) to unload cardiopulmonary baroreceptors by reducing central venous pressure (CVP) at rest and during dynamic exercise.
Measured maximal carotid baroreflex stimulus-response gain for heart rate (HR) and mean arterial pressure (MAP) across resting and exercise conditions.
Resting HR baroreflex gain increased with high-level LBNP from -0.31 ± 0.05 to -0.57 ± 0.23 beats·min⁻¹·mmHg⁻¹ CSP (P < 0.05), and combined exercise with low- or high-level LBNP elicited greater-than-additive HR gains (-0.83 ± 0.44 and -0.83 ± 0.17 beats·min⁻¹·mmHg⁻¹ CSP, P < 0.05).
The slope relating HR gain to CVP was significant at rest (0.07 ± 0.02 beats·min⁻¹·mmHg CSP⁻¹·mmHg CVP⁻¹, P < 0.01) and increased by 114% during dynamic exercise (P < 0.05).
Carotid baroreflex gain for MAP was not significantly altered by dynamic exercise or either level of LBNP (P > 0.05).

Structured PICO

Does cardiopulmonary baroreceptor unloading modulate carotid baroreflex control of heart rate during dynamic exercise in humans?

Population

Humans

Intervention

Dynamic exercise accompanied by two levels of cardiopulmonary baroreceptor unloading via lower body negative pressure (LBNP)

Comparator

Rest with and without LBNP, and exercise alone

Outcome

Maximal gain for carotid baroreflex control of heart rate (HR) and mean arterial pressure (MAP)surrogate

Main Result

p-value: p=<0.05

There is a tonic inhibitory interaction between cardiopulmonary baroreceptors and carotid baroreflex control of heart rate during exercise, which may improve cardiovascular regulation when central blood volume is reduced.

Cite This Study

Potts et al. (1995) studied this question. Lower body negative pressure (LBNP) and dynamic exercise vs. Rest and exercise alone was evaluated on Maximal gain for carotid baroreflex control of heart rate (p=<0.05). Exercise combined with lower body negative pressure resulted in reflex heart rate gains (-0.83 beats/min/mmHg) significantly greater than the sum of gains during exercise and LBNP alone (P<0.05).

synapsesocial.com/papers/6a1f1ae6e800cc4eef5529d2 https://doi.org/10.1152/ajpheart.1995.268.4.h1567

View Full Paper

Ask AI

Bookmark

Cardiopulmonary baroreceptors modulate carotid baroreflex control of heart rate during dynamic exercise in humans

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

Cardiopulmonary baroreceptors modulate carotid baroreflex control of heart rate during dynamic exercise in humans

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

Also Consider

Also Consider