Key result
Patients with pulmonary hypertension were unable to increase right ventricular end-systolic elastance during submaximal exercise compared to controls (Pinteraction < 0.001), leading to a deterioration in right ventricular-arterial coupling.
Why the study?
Does submaximal exercise reveal impaired right ventricular contractility and RV-arterial coupling in patients with precapillary pulmonary hypertension compared to controls?
Observational (n=24)
No
Does submaximal exercise reveal impaired right ventricular contractility and RV-arterial coupling in patients with precapillary pulmonary hypertension compared to controls?
Patients with pulmonary hypertension lack exertional right ventricular contractile reserve, leading to deteriorated RV-arterial coupling during exercise, which may explain their exercise intolerance.
Answers are grounded in this paper and cite their sources.
May underlie exercise intolerance in pulmonary hypertension; leaves open whether RV-arterial coupling is a modifiable target.
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Spruijt et al. (2015) conducted an observational in Precapillary pulmonary hypertension (n=24). Precapillary pulmonary hypertension vs. Control subjects without pulmonary hypertension was evaluated on Rest-to-exercise response in right ventricular end-systolic elastance (ΔEes) (p=<0.001). Patients with pulmonary hypertension were unable to increase right ventricular end-systolic elastance during submaximal exercise compared to controls (Pinteraction < 0.001), leading to a deterioration in right ventricular-arterial coupling.
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