March 1, 2002Cardiovascular Research

Vitronectin is up-regulated after vascular injury and vitronectin blockade prevents neointima formation

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Why the study?

Does vitronectin blockade prevent neointima formation and smooth muscle cell migration after vascular injury?

Population

Sprague-Dawley rats undergoing balloon carotid injury and human smooth muscle cells in vitro

Design

Preclinical

Follow-up

7 days

Authors

PDPascale DufourcqUniversité de Bordeaux

Discussion

Member takes

Implication

May support vitronectin blockade to limit neointimal hyperplasia; leaves open translation to human restenosis prevention.

Structured PICO

Does vitronectin blockade prevent neointima formation and smooth muscle cell migration after vascular injury?

Population

Sprague-Dawley rats undergoing balloon carotid injury and human smooth muscle cells in vitro

Intervention

Adventitial delivery of blocking antibodies to vitronectin (VN), alpha v beta 5, and beta 3 integrins

Outcome

Neointima formation (intimal area and intimal cell counts) and smooth muscle cell migrationsurrogate

Vitronectin blockade reduces neointima formation and smooth muscle cell migration following vascular injury, highlighting a potential therapeutic target for preventing restenosis.

Cite This Study

Pascale Dufourcq (2002) studied this question.

synapsesocial.com/papers/6a1f200f0a1e4e63fe915111 https://doi.org/10.1016/s0008-6363(01)00547-8

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