Key result
Low daily urine ammonium excretion was associated with a 46% higher risk of the composite outcome of death or ESRD compared to high excretion in black patients with hypertensive kidney disease (HR 1.46).
Why the study?
Does low urine ammonium excretion predict death or ESRD in black patients with hypertensive kidney disease?
Population
1,044 black patients aged 18-70 years with hypertensive CKD from the African American Study of Kidney…
Comparison
Low daily urine ammonium excretion vs High daily urine ammonium excretion
Design
Cohort
Authors
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Low urine ammonium may aid risk stratification in black hypertensive CKD; hypothesis-generating pending interventional trials.
Cohort (n=1,044)
Yes
Does low urine ammonium excretion predict death or ESRD in black patients with hypertensive kidney disease?
Hazard Ratio: 1.46 (95% CI 1.13–1.87)
Absolute Event Rate: 79% vs 46%
Low daily urine ammonium excretion is an independent predictor of death, ESRD, and incident acidosis in black patients with hypertensive CKD, even among those with normal serum bicarbonate.
Raphael et al. (2017) conducted a cohort in Hypertensive Kidney Disease (n=1,044). Low daily urine ammonium excretion (lowest tertile) vs. High daily urine ammonium excretion (highest tertile) was evaluated on Composite of death or ESRD (HR 1.46, 95% CI 1.13 to 1.87). Low daily urine ammonium excretion was associated with a 46% higher risk of the composite outcome of death or ESRD compared to high excretion in black patients with hypertensive kidney disease (HR 1.46).
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