Key result
Vascular dementia patients exhibited the highest incidence of new-onset depressive symptoms, which were more persistent and refractory to antidepressants compared to Alzheimer's patients.
Population
294 elderly subjects exhibiting different levels of cognitive performance, including cognitively normal…
Design
Cohort
Follow-up
mean 3.5 years
Authors
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May warrant closer monitoring for refractory depression in vascular dementia; leaves open whether targeted interventions improve outcomes.
Cohort (n=294)
Depressive symptoms in vascular dementia are more persistent and refractory to treatment compared to Alzheimer's dementia, where they often resolve spontaneously.
Li et al. (2001) conducted a cohort in Cognitive impairment and dementia (n=294). Cognitive impairment (MCI, DAT, VAD) vs. Normal cognition was evaluated on Prevalence, incidence and prognosis of depressive symptoms. Vascular dementia patients exhibited the highest incidence of new-onset depressive symptoms, which were more persistent and refractory to antidepressants compared to Alzheimer's patients.
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