Key result
MHC class II ligands induced inflammatory chemokine gene expression in human fibroblast-like synoviocytes, which was differentially inhibited by dexamethasone and IL-4.
Population
human fibroblast-like synoviocytes
Design
Preclinical
Authors
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May inform synovitis models; leaves open whether differential inhibition translates to clinical benefit.
MHC class II ligands induce inflammatory chemokines in human fibroblast-like synoviocytes, which can be differentially modulated by dexamethasone and IL-4.
Mehindate et al. (1994) studied this question. MHC class II ligands (superantigens and anti-MHC class II antibodies) was evaluated on Chemokine gene expression (RANTES, MCP-1, IL-8). MHC class II ligands induced inflammatory chemokine gene expression in human fibroblast-like synoviocytes, which was differentially inhibited by dexamethasone and IL-4.
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