Why the study?
Does radiation therapy to the spleen plus chemotherapy improve survival compared to chemotherapy alone in patients with chronic myelogenous leukemia?
Population
178 patients with chronic myelogenous leukemia from January 1948 through December 1967
Comparison
Radiation therapy to the spleen and chemotherapy vs Chemotherapy alone (n=50)
Design
Cohort
Authors
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Splenic radiation added to chemotherapy was not associated with CML survival benefit; hypothesis-generating and should not yet change practice.
Does radiation therapy to the spleen plus chemotherapy improve survival compared to chemotherapy alone in patients with chronic myelogenous leukemia?
In a retrospective cohort of CML patients, adding splenic radiation to chemotherapy did not improve median survival compared to chemotherapy alone.
Monfardini et al. (1973) studied this question.
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