Population
Humans with left ventricular hypertrophy due to aortic stenosis, and patients without LVH undergoing heart…
Design
Case-control
Authors
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LVH-associated beta1-AR downregulation and impaired AC response; hypothesis-generating for adrenergic modulation, should not yet change practice.
Left ventricular hypertrophy due to pressure overload is associated with down-regulation of beta 1-AR, increased beta 2-AR density, and impaired transmembrane signaling in the left ventricle.
Galinier et al. (1994) studied this question.
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