Key result
In the intact functioning canine left ventricle, the interaction of volume with pressure-time was the most significant overall correlate of oxygen consumption (r=0.93).
Population
Intact functioning canine left ventricle (hypervolemic dog model)
Design
Preclinical
Authors
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Supports volume-pressure determinants of MVO2 in intact hearts; leaves open translation to human energetics or therapy.
Effect estimate: r=0.93
Increases in ventricular volume and pressure are accompanied by increased ventricular oxygen consumption, highlighting the relationship between myocardial wall stress and energy requirements.
Rolett et al. (1965) studied Hypervolemia (canine model). Whole blood infusion was evaluated on Left ventricular oxygen consumption correlates (r=0.93). In the intact functioning canine left ventricle, the interaction of volume with pressure-time was the most significant overall correlate of oxygen consumption (r=0.93).
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