Key result
Nitroglycerin induced coronary vasodilatation secondary to changes in myocardial oxygen requirements, and caused a general decrease in peripheral and pulmonary pressures.
Why the study?
Does nitroglycerin alter coronary circulation and hemodynamics in normal or nearly normal subjects?
Population
10 normal or nearly normal subjects
Design
Case_series
Authors
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Should not change nitroglycerin use in patients; hypothesis-generating for mechanism in normal versus diseased coronaries.
Does nitroglycerin alter coronary circulation and hemodynamics in normal or nearly normal subjects?
Nitroglycerin's coronary vasodilatory effect in humans appears secondary to altered myocardial oxygen requirements rather than direct smooth muscle action, and it lowers peripheral and pulmonary pressures.
Brachfeld et al. (1959) studied Normal and mild cardiac subjects (n=10). Nitroglycerin was evaluated on Coronary circulation and hemodynamic changes. Nitroglycerin induced coronary vasodilatation secondary to changes in myocardial oxygen requirements, and caused a general decrease in peripheral and pulmonary pressures.
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