Acceleration and Selectivity of 1,3-Dipolar Cycloaddition Reactions Included in a Polar 4 + 2 Octa-imine Bis-calix4pyrrole Cage

-oxide) carrying the reacting groups in its two functionalized hemispheres. The two latter characteristics render the distance between the reacting groups (azido and ethynyl) almost fixed by design, thus allowing or not achieving the transition state's geometry. We support our hypothesis with the help of DFT calculations of the inclusion complexes' structures.