Key result
Echocardiography and ECG examination revealed no evidence of cardiac involvement or cardiomyopathy in 9 family members with hypokalaemic periodic paralysis and permanent muscular weakness.
Why the study?
Is there evidence of cardiomyopathy in patients with hypokalaemic periodic paralysis and permanent muscular weakness?
Observational (n=9)
Is there evidence of cardiomyopathy in patients with hypokalaemic periodic paralysis and permanent muscular weakness?
Echocardiography and ECG screening revealed no evidence of cardiomyopathy in a family with hypokalaemic periodic paralysis and permanent muscular weakness.
No cardiomyopathy found in this family; leaves open cardiac risk in hypokalaemic periodic paralysis and requires larger studies.
The results are reported of cardiological examinations, including echocardiography, in nine members of a family suffering from hypokalaemic periodic paralysis, associated with permanent muscular weakness. The studies were performed in periods between attacks of paralysis. The slowly progressive permanent muscular weakness which is found in most of the patients with hypokalaemic periodic paralysis resembles a limb-girdle type dystrophy. Involvement of cardiac muscle is not uncommon in patients with limb-girdle dystrophy. Using a combination of echocardiography and ECG examination, nowadays the most sensitive screening method for the detection of cardiomyopathy, no evidence was obtained for cardiac involvement in hypokalaemic periodic paralysis patients with permanent muscular weakness.
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Schipperheyn et al. (2009) conducted an observational in Hypokalaemic periodic paralysis (n=9). Hypokalaemic periodic paralysis with permanent muscular weakness was evaluated on Cardiac involvement (cardiomyopathy) detected by echocardiography and ECG. Echocardiography and ECG examination revealed no evidence of cardiac involvement or cardiomyopathy in 9 family members with hypokalaemic periodic paralysis and permanent muscular weakness.
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