Key result
taVNS shows promise for safely improving sleep quality and negative emotions in patients with insomnia.
Why the study?
Insomnia disorder is common and current treatments remain unsatisfactory, while transcutaneous auricular vagus nerve stimulation (taVNS) represents a potential alternative therapy.
Does transcutaneous auricular vagus nerve stimulation (taVNS) improve sleep quality in patients with insomnia disorder?
Does transcutaneous auricular vagus nerve stimulation (taVNS) improve sleep quality in patients with insomnia disorder?
taVNS is a promising, non-invasive alternative therapy for insomnia disorder that modulates brain networks and autonomic function, though larger high-quality trials are needed.
taVNS may aid insomnia symptoms; high-quality RCTs needed before clinical adoption.
Insomnia disorder is a very common disease that has received widespread attention in modern society, but the effects of current treatments for insomnia disorder are far from satisfactory. Transcutaneous auricular vagus nerve stimulation (taVNS) is a safe and highly tolerated method, and it might be an alternative therapy for patients with insomnia disorder. This narrative review synthesizes clinical and mechanistic evidence of taVNS for insomnia disorder, critically analyzing its multimodal therapeutic actions from the perspectives of brain networks modulation, neurotransmitter-hormone axis regulation, anti-inflammatory effects, and changes in autonomic nerve function. Existing studies have shown that taVNS can improve sleep quality, quality of life and the accompanying negative emotions. However, the deficiencies in the current trial methods may lead to a reduction in the quality of evidence. Although existing findings support taVNS as a promising strategy for treating insomnia, more high-quality trials are needed to verify its benefits and elucidate its mechanisms of action.
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Liu et al. (2025) conducted a review in Insomnia disorder. Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) was evaluated. Transcutaneous auricular vagus nerve stimulation is a promising and safe alternative therapy that improves sleep quality and accompanying negative emotions in patients with insomnia disorder.
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