Key result
One-year aerobic exercise training significantly reduced cerebrovascular impedance modulus from 1.05 to 0.95 mmHg·s·cm-1 in sedentary older adults compared to stretching and toning.
Why the study?
Estimation of cerebrovascular impedance is essential for understanding dynamic cerebral blood flow regulation.
Does a 1-year aerobic exercise training program reduce cerebrovascular impedance in cognitively normal, sedentary older adults?
RCT (n=73)
Open-label with blinded outcome assessment
Stratified block randomization
No
Does a 1-year aerobic exercise training program reduce cerebrovascular impedance in cognitively normal, sedentary older adults?
Absolute Event Rate: 0.95% vs 1.01%
p-value: p=0.017
A 1-year aerobic exercise training program significantly reduces cerebrovascular impedance in sedentary older adults, suggesting a mechanism by which exercise improves brain perfusion and buffers pulsatile pressure.
Supports aerobic exercise to reduce cerebrovascular impedance in sedentary older adults; extends RCT evidence on exercise and cerebral hemodynamics.
Estimation of cerebrovascular impedance is essential for understanding dynamic cerebral blood flow regulation. This randomized controlled trial demonstrated that aerobic exercise training reduced cerebrovascular impedance in older adults, which may benefit brain perfusion.
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Sugawara et al. (2022) conducted an RCT in Sedentary lifestyle in older adults (n=73). Aerobic exercise training vs. Stretching and toning was evaluated on Cerebrovascular impedance modulus (Z) at 0.78-3.12 Hz (p=0.017). One-year aerobic exercise training significantly reduced cerebrovascular impedance modulus from 1.05 to 0.95 mmHg·s·cm-1 in sedentary older adults compared to stretching and toning.
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