Noninvasive indices of baroreceptor sensitivity correlated with the phenylephrine method (r=0.70) but had wide limits of agreement, indicating they should not be used as clinical alternatives.
Observational (n=52)
Do noninvasive indices of baroreceptor sensitivity agree with the phenylephrine method in post-myocardial infarction patients?
Noninvasive baroreflex sensitivity assessments have wide limits of agreement with the phenylephrine method and should not be used as clinical alternatives in post-MI patients.
Effect estimate: r=0.70
BACKGROUND: Depressed baroreflex sensitivity obtained by means of a phenylephrine test plays a prognostic role in patients with a previous myocardial infarction. Our purpose was to evaluate the correlation and agreement between the baroreflex sensitivity obtained with phenylephrine and that obtained by two noninvasive methods: the alpha-index and sequence analysis. METHODS AND RESULTS: The alpha-index was measured by means of the spectral analysis of RR and systolic blood pressure variabilities in both the high- and low-frequency bands; sequences were identified from simultaneously recorded time series in which the RR and systolic blood pressure concurrently increased or decreased. Noninvasive baroreflex sensitivity tests were performed during both spontaneous and controlled respiration. Fifty-two consecutive patients with recent myocardial infarction underwent the analyses. Although the correlations between phenylephrine and either of the noninvasive methods were always significant, those found during controlled respiration had the highest r values (r=.70). However, the limits of agreement calculated by means of the Bland and Altman method were wide for both noninvasive methods. CONCLUSIONS: The results obtained by means of noninvasive baroreflex sensitivity assessments should not be used in clinical practice as an alternative to those obtained by the phenylephrine method.
Pitzalis et al. (Tue,) conducted a observational in Recent myocardial infarction (n=52). Noninvasive indices of baroreceptor sensitivity (alpha-index and sequence analysis) vs. Phenylephrine method was evaluated on Correlation and agreement between baroreflex sensitivity obtained with phenylephrine and noninvasive methods (r=0.70). Noninvasive indices of baroreceptor sensitivity correlated with the phenylephrine method (r=0.70) but had wide limits of agreement, indicating they should not be used as clinical alternatives.