Mass Spectrometric Screening of Enantioselective Diels–Alder Reactions

A rapid cat. scan: Mass spectrometric monitoring of reaction intermediates of the retro-Diels–Alder reaction has allowed the rapid screening of catalysts for enantioselective Diels–Alder reactions (see scheme). Copper catalysts as well as metal-free organocatalysts were tested. A protocol for the simultaneous screening of catalyst mixtures has also been developed, which offers new possibilities for high-throughput catalyst development. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2008/z705082_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.