Key result
Obesity disrupts bidirectional adipose tissue communication with major organs, offering therapeutic targets for metabolic health.
Why the study?
A better understanding of multi-organ interaction mechanisms is needed to address the rising incidence of obesity and its associated chronic conditions such as cardiovascular disease and diabetes.
This review highlights the complex multi-organ crosstalk involving adipose tissue in obesity, emphasizing its role in systemic metabolic and cardiovascular complications.
Answers are grounded in this paper and cite their sources.
Adipose crosstalk offers candidate targets in obesity; leaves open whether interventions improve cardiometabolic outcomes.
A high-fat diet and physical inactivity are key contributors to obesity, predisposing individuals to various chronic diseases, such as cardiovascular disease and diabetes, which involve multiple organs and tissues. To better understand the role of multi-organ interaction mechanisms in the rising incidence of obesity and its associated chronic conditions, treatment and prevention strategies are being extensively investigated. This review examines the signaling mechanisms between different tissues and organs, with a particular focus on the crosstalk between adipose tissue and the muscle, brain, liver, and heart, and potentially offers new strategies for the treatment and management of obesity and its complications.
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Jia et al. (2024) conducted a review in Obesity. Adipose tissue engages in complex bidirectional communication with the muscle, brain, liver, and heart, which is disrupted in obesity and presents potential therapeutic targets for metabolic health.
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