Key result
CNP modulates diverse cardiovascular processes and shows emerging therapeutic potential.
Why the study?
There is substantial interest in mimicking the biological activity of C-type natriuretic peptide for therapeutic gain across cardiovascular and diverse non-cardiovascular organ systems.
This review highlights the diverse regulatory roles of C-type natriuretic peptide (CNP) across cardiovascular and non-cardiovascular systems and its potential as a therapeutic target.
CNP's multi-system roles support targeted therapy development; leaves open clinical translation pending prospective trials.
C-type natriuretic peptide (CNP) represents the 'local' member of the natriuretic peptide family, functioning in an autocrine or paracrine capacity to modulate a hugely diverse portfolio of physiological processes. Whilst the best-characterised of these regulatory roles are in the cardiovascular system, akin to its predominantly endocrine siblings atrial (ANP) and brain (BNP) natriuretic peptides, CNP governs many additional, unrelated mechanisms including bone growth, gamete maturation, auditory processing, and neuronal integrity. Furthermore, there is currently great interest in mimicking the biological activity of CNP for therapeutic gain in many of these disparate organ systems. Herein, we provide an overview of the physiology, pathophysiology and pharmacology of CNP in both cardiovascular and non-cardiovascular settings.
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Dickinson et al. (2024) reported a review. C-type natriuretic peptide (CNP) was evaluated. C-type natriuretic peptide (CNP) modulates diverse physiological processes in cardiovascular and non-cardiovascular systems, with emerging interest in its therapeutic potential.
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