What question did this study set out to answer?

To develop and evaluate a proof-of-concept surface-enhanced Raman spectroscopy (SERS) biosensing platform for real-time, reversible detection of lactate and sequential lactate–glucose monitoring.

August 10, 2007Analytical Chemistry

Lactate and Sequential Lactate−Glucose Sensing Using Surface-Enhanced Raman Spectroscopy

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Authors

NSNilam C. ShahCara Therapeutics (United States)OLOlga LyandresUniversity of Central Florida JWJoseph T. WalshNorthwestern University

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Implication

Proof-of-concept study demonstrates reversible SERS-based lactate and glucose detection in buffer solutions, indicating potential for real-time multianalyte physiological monitoring.

Key Points

To develop and evaluate a proof-of-concept surface-enhanced Raman spectroscopy (SERS) biosensing platform for real-time, reversible detection of lactate and sequential lactate–glucose monitoring.
Engineered a SERS sensor substrate using a mixed decanethiol and mercaptohexanol partition layer to facilitate molecular capture.
Evaluated sensor reversibility through alternating exposures to aqueous analyte solutions and buffer, and quantified lactate across physiological concentrations (6–240 mg/dL) in phosphate-buffered saline using multivariate analysis.
Partitioning and departitioning time constants for lactate were both approximately 30 seconds.
Multivariate quantification of physiological lactate levels (6–240 mg/dL) achieved a root-mean-square error of prediction of 39.6 mg/dL in phosphate-buffered saline.
Sequential exposures to glucose and lactate demonstrated complete partitioning and departitioning reversibility for both target analytes.

Cite This Study

Shah et al. (2007) studied this question.

synapsesocial.com/papers/6a1f57fed09bc027e48357d0 https://doi.org/10.1021/ac0704107

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Implication

Proof-of-concept study demonstrates reversible SERS-based lactate and glucose detection in buffer solutions, indicating potential for real-time multianalyte physiological monitoring.

Lactate and Sequential Lactate−Glucose Sensing Using Surface-Enhanced Raman Spectroscopy

Discussion

Member takes

Implication

Key Points

Cite This Study

Lactate and Sequential Lactate−Glucose Sensing Using Surface-Enhanced Raman Spectroscopy

Discussion

Member takes

Implication

Key Points

Cite This Study

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