Natural Thermal Water Consumption Could be Capable of Improving Gut Mycobiome in Dogs with Inflammatory Bowel Disease and Dermatological Manifestations: Randomized Clinical Study

Objective: Given the gut microbiome is a supreme immunological and metabolic organ, much data is recognized within the intestinal bacteria whereas the prevalence along with phylogenetic interpretation of fungal organisms participating within intestinal ecosystem have not explored convincingly among dogs with inflammatory bowel disease (IBD). In the present study, the present authors' for the first time a) described the fungal gut mycobiome, b) analyzed disbiosis network for fungal kigdom, c) detected the efficacy of natural thermal water (nTW) on gut mycobiome. Material and Methods: For these purpose, MIDOG All-in One Microbial Test targetting Next-Generation DNA Sequencing was used to determining of fungal microbiome prior to and thereafter nTW in a total of 13 dogs with IBD. Results: Aspergillus sp. (n=5), Acremonium hyalinulum (n=4), Acremonium fusidoides-hansfordii (n=4) were frequently isolated as fungal pathogens whereas case VII exhibited 5 different species (at most) and 4 other dogs presented solely 1 species. Interestingly a 6 week course of nTW consumption resulted with disapperance of fungal pathogens in 12 out of 13 cases. On behalf of repeated Next-Generation DNA Sequencing at 6th week analysis of all 12 cases wered deemed more diverse gut mycobiome. Conclusion: Obtained data preserved protective/restorative roles of nTW on gut mycobiome in dogs with IBD and dermatological manifestations ivolved at the present study.