Effect of Exercise and Non-exercise Interventions on Cardiac Angiogenesis in Diabetes Mellitus Patients: A Review

Background: It has been shown that about 80% of deaths in diabetic patients are due to cardiovascular disorders, which are called Diabetic Heart Disease or DHD, the most important of which are dysfunction and vascular damage, and consequently the stopping of coronary angiogenesis. Despite the many advances made in the field of medical research and the long-standing clinical history of diabetes mellitus, the risk of cardiovascular disease associated with diabetes has not been reduced. Method: Our search was performed by typing the words HIIT, MICT, Diabetic Heart Disease, MicroRNA, Cardiac Angiogenesis in pubmed. We reviewed the literature using articles that were relevant to our field of work. conclusion: Researchers have proposed different exercise programs to improve cardiovascular complications in diabetic patient, and their prominent role in improving the complications associated with microangiopathy compared to non-exercise interventions (hormone, complementary therapies, pharmaceutical methods, etc.) in these proven patients. but so far no study has been done to compare the effectiveness of exercise or non-exercise interventions on the improvement of microvascular complications in DHD patients. Therefore, this review article compares the types of interventions that affect the angiogenesis of patients with a history of DHD.