Key result
Baroreflex sensitivity was significantly reduced in patients with very severe, severe, and moderate COPD compared to mild COPD (p=0.002), and correlated with lung function.
Why the study?
Chronic obstructive pulmonary disease predisposes patients to cardiovascular morbidity and mortality, but literature evaluating the relationship between baroreflex sensitivity and disease severity in COPD is limited.
Cross-Sectional (n=130)
No
Baroreflex sensitivity is significantly reduced in male COPD patients as disease severity increases, highlighting a potential mechanism for the increased cardiovascular risk observed in this population.
Reduced baroreflex sensitivity with COPD severity may heighten cardiovascular risk; hypothesis-generating observation requiring prospective studies.
Background: Chronic obstructive pulmonary disease (COPD) is systemic disorder which causes autonomicdysfunction and predisposes patients to cardiovascular mortality and morbidity. FEV1 is a predictor ofcardiovascular events in COPD patients and Baroreflex sensitivity (BRS) is most reliable tool to measureautonomic dysfunction. There is paucity of literature, revealing the relationship of BRS with disease severityin COPD patients.Objective: In our study we intended to assess BRS among different stages of COPD (GOLD CRITERIA)and also identify the association of BRS with disease severity.Method: This study was done in collaboration between Department of Physiology & Department ofPulmonary medicine, JIPMER. It is a descriptive study done on (n=130) male COPD patients. Anthropometricparameters (height, weight, BMI, W/H ratio), basal parameters, BRS (using Finapres) & PFT (using SpirolabIII) parameters were assessed in them. Later, based on the GOLD stage criteria (Mild, Moderate, Severe,Very severe) they were divided into 4 sub-groups. Data was analyzed by SPSS 16.0 version software.One-way ANOVA (>2 groups) was used to find any Statistical difference between the groups. Correlationsbetween the variables were done using Pearson correlation test.Results: Statistically significant (p<0.05)difference in BRS between different stages of COPD was determinedby Kruskal- Wallis test and the post – hoc (Dunn’s) test revealed that BRS levels were significantly reducedin very severe, severe and moderate COPD patients when compared to mild COPD patients. Significantpositive Correlation (r=.332, p=0.05) was found between BRS and FEV1.Conclusion: Baroreflex sensitivity is reduced in male patients of COPD and BRS correlated with lungfunction and disease severity.
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Gaur Ganesan R. (2020) conducted a cross-sectional in Chronic Obstructive Pulmonary Disease (COPD) (n=130). COPD severity (GOLD stages) vs. Mild COPD was evaluated on Baroreflex sensitivity (BRS) (p=0.002). Baroreflex sensitivity was significantly reduced in patients with very severe, severe, and moderate COPD compared to mild COPD (p=0.002), and correlated with lung function.
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