Siponimod and Cognition in Secondary Progressive Multiple Sclerosis

Ralph H. B. Benedict; Davorka Tomic; Bruce Cree; Robert J. Fox; Gavin Giovannoni; Amit Bar‐Or; Ralf Gold; Patrick Vermersch; H. Pöhlmann; Ian M. Wright; Göril Karlsson; Frank Dahlke; Christian Wolf; Ludwig Kappos

doi:10.1212/wnl.0000000000011275

January 18, 2021Neurology

Siponimod and Cognition in Secondary Progressive Multiple Sclerosis

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Key Points

This research aims to evaluate the impact of siponimod on cognitive processing speed in secondary progressive multiple sclerosis patients.
Randomized controlled trial involving 1,651 patients with SPMS, randomized 2:1 to siponimod 2 mg/d or placebo.
Cognitive assessments done using SDMT, PASAT, and BVMT-R at baseline, 6-month intervals, and treatment end.
The study was double-blind and placebo-controlled.
Siponimod resulted in a significant improvement in SDMT scores among treated patients.
Patients on siponimod were significantly less likely to experience a ≥4-point decrease in SDMT score.
There was a significantly higher chance of achieving a ≥4-point increase in SDMT score, indicating clinically meaningful enhancement.

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Implication

Randomized trial investigates siponimod's impact on cognitive processing speed in patients with secondary progressive multiple sclerosis, suggesting its efficacy.

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Cite This Study

Benedict et al. (2021) studied this question.

synapsesocial.com/papers/6a1f668dd03d2b72e723624d https://doi.org/10.1212/wnl.0000000000011275

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Siponimod and Cognition in Secondary Progressive Multiple Sclerosis

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Siponimod and Cognition in Secondary Progressive Multiple Sclerosis

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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