Key result
Atrial fibrillation was associated with elevated ventricular fibrosis and CD3+/CD45+ cell counts (P<0.001), with significant correlation between fibrosis and inflammation in both ventricles.
Why the study?
Is atrial fibrillation associated with increased fibrosis and lymphomononuclear infiltration in the ventricular myocardium?
Observational
Is atrial fibrillation associated with increased fibrosis and lymphomononuclear infiltration in the ventricular myocardium?
p-value: p=<0.001
Atrial fibrillation is strongly associated with histological signs of chronic inflammation and fibrosis in the ventricular myocardium, independent of age or comorbidities.
AF may involve ventricular myocardium via inflammation-fibrosis; extends atrial observations but leaves open clinical relevance.
AIMS: Chronic inflammation in the atrial myocardium was shown to play an important role in the development of atrial fibrosis in patients with atrial fibrillation (AF). However, it is not clear to what extent atrial inflammatory reaction associated with AF extends on the ventricular myocardium. Our aim was to assess the extent of fibrosis and lymphomononuclear infiltration in human ventricular myocardium and explore its association with AF. METHODS AND RESULTS: . Fibrosis extent, CD3+ and CD45+ cell counts were elevated in AF patients at all sites (P < 0.001 for all). Fibrosis extent demonstrated correlation with both CD3+ and CD45+ cell counts in the right (r = 0.781, P < 0.001 for CD45+ and r = 0.720, P < 0.001 for CD3+) and the left (r = 0.515, P = 0.004 for CD45+ and r = 0.573, P = 0.001 for CD3+) ventricles. Neither fibrosis nor inflammatory cell count showed association with either age or comorbidities. CONCLUSION: Histological signs of chronic inflammation affecting ventricular myocardium are strongly associated with AF and demonstrate significant correlation with fibrosis extent that cannot be explained by cardiovascular comorbidities otherwise.
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Митрофанова et al. (2016) conducted an observational in Atrial fibrillation. Atrial fibrillation vs. Non-AF patients was evaluated on Fibrosis extent, CD3+ and CD45+ cell counts in ventricular myocardium (p=<0.001). Atrial fibrillation was associated with elevated ventricular fibrosis and CD3+/CD45+ cell counts (P<0.001), with significant correlation between fibrosis and inflammation in both ventricles.
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