Key result
Obesity at age 45 was associated with 6.0 fewer years lived free of cardiovascular disease in men and 8.4 fewer years in women compared to normal weight individuals.
Why the study?
Does obesity at age 45 reduce the number of years lived free of cardiovascular disease compared to normal weight?
Cohort (n=2,551)
Does obesity at age 45 reduce the number of years lived free of cardiovascular disease compared to normal weight?
Obesity in midlife significantly reduces overall life expectancy and the number of years lived free of cardiovascular disease, while increasing the years lived with cardiovascular morbidity.
Supports midlife obesity prevention to extend CVD-free years; leaves open causal effects of weight loss in RCTs.
OBJECTIVE: To determine the differences in number of years lived free of cardiovascular disease (CVD) and number of years lived with CVD between men and women who were obese, pre-obese, or normal weight at 45 years of age. RESEARCH METHODS AND PROCEDURES: We constructed multistate life tables for CVD, myocardial infarction, and stroke, using data from 2551 enrollees (1130 men) in the Framingham Heart Study who were 45 years of age. RESULTS: Obesity and pre-obesity were associated with fewer number of years free of CVD, myocardial infarction, and stroke and an increase in the number of years lived with these diseases. Forty-five-year-old obese men with no CVD survived 6.0 years [95% confidence interval (CI), 4.1; 8.1] fewer than their normal weight counterparts, whereas, for women, the difference between obese and normal weight subjects was 8.4 years (95% CI: 6.2; 10.8). Obese men and women lived with CVD 2.7 (95% CI: 1.0; 4.4) and 1.4 years (95% CI: -0.3; 3.2) longer, respectively, than normal weight individuals. DISCUSSION: In addition to reducing life expectancy, obesity before middle age is associated with a reduction in the number of years lived free of CVD and an increase in the number of years lived with CVD. Such information is paramount for preventive and therapeutic decision-making by individuals and practitioners alike.
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Silva et al. (2006) conducted a cohort in Cardiovascular disease (n=2,551). Obesity and pre-obesity vs. Normal weight was evaluated on Number of years lived free of cardiovascular disease (6.0 fewer years (men), 8.4 fewer years (women), 95% CI 4.1; 8.1 (men), 6.2; 10.8 (women)). Obesity at age 45 was associated with 6.0 fewer years lived free of cardiovascular disease in men and 8.4 fewer years in women compared to normal weight individuals.
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