Key result
Activation of the mitochondrial calcium uniporter complex with spermine reduced the calcium transient alternans ratio by 76% (from 0.49 to 0.12, P<0.0001) in isolated rabbit atrial myocytes.
Why the study?
Does pharmacological activation of mitochondrial calcium uptake reduce pacing-induced calcium alternans in isolated rabbit atrial myocytes?
Does pharmacological activation of mitochondrial calcium uptake reduce pacing-induced calcium alternans in isolated rabbit atrial myocytes?
Pharmacological activation of mitochondrial calcium uptake and retention protects against calcium alternans in atrial myocytes, highlighting a potential therapeutic target for preventing alternans-related arrhythmias like atrial fibrillation.
Does not yet warrant clinical translation; leaves open mitochondrial calcium uptake as a target for atrial arrhythmia prevention.
This study provides conclusive evidence that mitochondrial Ca uptake and retention protects from Ca alternans, whereas uptake inhibition enhances Ca alternans. The data suggest pharmacological mitochondrial Ca cycling modulation as a potential therapeutic strategy for alternans-related cardiac arrhythmia prevention.
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Oropeza‐Almazán et al. (2020) studied Calcium alternans (n=49). Spermine vs. Control (baseline) was evaluated on Calcium transient alternans ratio (AR) (76% reduction, p=<0.0001). Activation of the mitochondrial calcium uniporter complex with spermine reduced the calcium transient alternans ratio by 76% (from 0.49 to 0.12, P<0.0001) in isolated rabbit atrial myocytes.
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