23 Osteogenesis in the Interior of Intramuscular Implants of Decalcified Bone Matrix

KAREL A. VAN DE PUTTE; Marshall R. Urist

doi:10.1097/00003086-196500430-00026

January 1, 1965Clinical Orthopaedics and Related Research

23 Osteogenesis in the Interior of Intramuscular Implants of Decalcified Bone Matrix

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Key Points

To evaluate the occurrence and pattern of bone formation within the interior of decalcified bone matrix implanted into muscle tissue.
Prepared decalcified bone matrix constructs for experimental evaluation.
Implanted the matrix specimens into intramuscular sites in vivo to assess ectopic osteogenesis.
New bone formation localized specifically within the interior compartments of the intramuscular matrix implants.
Implanted matrix stimulated ectopic osteogenesis without requiring pre-existing skeletal bone tissue.

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Implication

Experimental study demonstrates osteogenesis within intramuscular implants of decalcified bone matrix, suggesting an intrinsic inductive capacity for bone formation.

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PUTTE et al. (1965) studied this question.

synapsesocial.com/papers/6a1f71d281d56f934c2ac4ca https://doi.org/10.1097/00003086-196500430-00026

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23 Osteogenesis in the Interior of Intramuscular Implants of Decalcified Bone Matrix

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23 Osteogenesis in the Interior of Intramuscular Implants of Decalcified Bone Matrix

Key Points

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Implication

Abstract

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