Key result
Infection of pigs with high virulence African swine fever virus isolates significantly increased CXCL10 and CCL2 levels compared to low virulence isolates, potentially enhancing monocyte recruitment and viral dissemination.
Population
Pigs infected with African swine fever virus (ASFV), n=27 across two experiments.
Comparison
Infection with high virulence ASFV isolates vs Infection with low virulence ASFV isolate and…
Design
Preclinical
Follow-up
Up to 26 days post-infection
Authors
Loading...
Animal data link high-virulence ASFV to elevated CXCL10/CCL2; hypothesis-generating for pathogenesis without immediate clinical implications.
High virulence African swine fever virus isolates induce significantly greater expression of chemokines CXCL10 and CCL2 compared to low virulence isolates, potentially contributing to pathogenesis via monocyte recruitment.
Fishbourne et al. (2013) studied African swine fever virus (ASFV) infection (n=27). High virulence ASFV isolates (Benin 97/1, Uganda 1965) vs. Low virulence ASFV isolate (OURT88/3) and uninfected pigs was evaluated on CXCL10 and CCL2 mRNA and protein levels in blood. Infection of pigs with high virulence African swine fever virus isolates significantly increased CXCL10 and CCL2 levels compared to low virulence isolates, potentially enhancing monocyte recruitment and viral dissemination.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: