January 16, 2008Journal of General Virology

Comparison of the genome sequences of non-pathogenic and pathogenic African swine fever virus isolates

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Population

African swine fever virus isolates

Design

Preclinical

Authors

DCDavid A. ChapmanAstraZeneca (United Kingdom)VTVasily TcherepanovUniversity of Victoria CUChris UptonUniversity of London

Discussion

Member takes

Implication

May inform ASFV vaccine attenuation strategies; leaves open functional validation of multigene family roles in swine.

Structured PICO

Population

African swine fever virus (ASFV) isolates (non-pathogenic OURT88/3 from Portugal, highly pathogenic Benin 97/1 from West Africa, and tissue culture-adapted BA71V)

Intervention

Genome sequencing and annotation

Outcome

Genomic coding sequences and genetic variability

Genomic comparison of ASFV isolates reveals specific deletions and ORF interruptions that may explain differences in viral pathogenicity.

Cite This Study

Chapman et al. (2008) studied this question.

synapsesocial.com/papers/6a7123a335aa2c282ce2737d https://doi.org/10.1099/vir.0.83343-0

View Full Paper

Ask AI

Bookmark

Comparison of the genome sequences of non-pathogenic and pathogenic African swine fever virus isolates

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Comparison of the genome sequences of non-pathogenic and pathogenic African swine fever virus isolates

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider