Key result
Comparative genomic analysis revealed that the virulent African swine fever virus BA71 strain and the attenuated BA71V strain are largely identical, with a small number of specific genetic changes likely responsible for the loss of virulence.
Population
African Swine Fever Virus (ASFV) strains BA71 and BA71V
Comparison
Genome sequencing and comparative analysis vs BA71V genome sequence
Design
Preclinical
Authors
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May inform ASFV vaccine attenuation strategies; leaves open causal roles of identified changes in swine.
Comparative genomic analysis of virulent and avirulent ASFV strains identifies specific genetic changes potentially responsible for virulence.
Rodrı́guez et al. (2015) studied African swine fever (n=5). ASFV BA71 strain was evaluated on Mortality. Comparative genomic analysis revealed that the virulent African swine fever virus BA71 strain and the attenuated BA71V strain are largely identical, with a small number of specific genetic changes likely responsible for the loss of virulence.
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