Why the study?
Does manipulation of loading conditions affect regional segmental motion in acutely ischemic myocardium in conscious dogs?
Population
7 conscious dogs, instrumented with sonomicrometers, with acute coronary occlusion
Comparison
Manipulation of loading conditions vs Different loading conditions
Design
Preclinical
Authors
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Preload reduction augments ischemic segment motion in dogs; leaves open translation to human acute ischemia assessment.
Does manipulation of loading conditions affect regional segmental motion in acutely ischemic myocardium in conscious dogs?
In acutely ischemic myocardium, systolic bulging is load-dependent and relies on preload tension, while shortening during isovolumic relaxation is a completely passive phenomenon.
Akaishi et al. (1986) studied this question.
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