Key result
A higher Healthy Ageing Index score was inversely associated with 10-year cardiovascular disease risk, with each 1/7 unit increase reducing the odds of a cardiovascular event by 53% (OR 0.47).
Why the study?
Does a higher Healthy Ageing Index reduce 10-year CVD incidence in apparently healthy individuals?
Cohort (n=853)
Does a higher Healthy Ageing Index reduce 10-year CVD incidence in apparently healthy individuals?
Odds Ratio: 0.47 (95% CI 0.28–0.8)
p-value: p=0.005
A higher Healthy Ageing Index is significantly associated with a reduced 10-year risk of cardiovascular disease in apparently healthy individuals.
May inform CVD risk assessment in healthy adults; leaves open whether index-targeted interventions reduce events.
OBJECTIVES: The aim of the study was to understand determinants of ageing in relation to future cardiovascular disease (CVD) events at population level, and to explore determinants of healthy ageing and its relation to 10-year CVD incidence among apparently healthy individuals. METHODS: In the context of the ATTICA study 453 apparently healthy men (45±13 years) and 400 women (44±18 years) with complete psychological evaluation were studied and followed during 2002-2012. Healthy Ageing Index (HAI) (range 0-7) was calculated based on socio-economical, bio-clinical, psychological, and lifestyle characteristics (i.e. dietary habits and physical activity) of the participants during the baseline examination. CVD incidence during the follow-up period was defined according to ICD-10 criteria. RESULTS: Healthy Ageing Index was inversely associated with higher 10-year CVD risk (OR per 1/7 (95% CI): 0.47 (0.28, 0.80). Age and sex-adjusted determinants of healthy ageing were abnormal waist to hip ratio (p<0.001), increased coffee consumption (p=0.04), reduced basic metabolic rhythm (p<0.001), increased triglycerides (p=0.003), and C-reactive protein levels (p=0.02), as aggravating factors, while moderate alcohol consumption (p=0.002) was identified as a positive influential parameter. CONCLUSIONS: Understanding healthy ageing, as a dominant factor of CVD development, provides a new direction for better prevention efforts focused on healthy ageing at both population and individual level.
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Kollia et al. (2018) conducted a cohort in Cardiovascular disease (n=853). Healthy Ageing Index vs. Lower Healthy Ageing Index score was evaluated on 10-year cardiovascular disease incidence (OR 0.47, 95% CI 0.28, 0.80, p=0.005). A higher Healthy Ageing Index score was inversely associated with 10-year cardiovascular disease risk, with each 1/7 unit increase reducing the odds of a cardiovascular event by 53% (OR 0.47).
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