What question did this study set out to answer?

This study investigates how different isoform-specific inhibitors of the PI3K pathway affect cancer cell viability, particularly in relation to PTEN status.

January 26, 2010Cancer Research

Isoform-Specific Phosphoinositide 3-Kinase Inhibitors Exert Distinct Effects in Solid Tumors

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Authors

KEKyle A. EdgarSunesis (United States)JWJeffrey J. WallinGilead Sciences (United States)MBMegan BerryUniversidad de la República de Uruguay

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Randomized trial examines distinct impacts of PI3K inhibitors in solid tumors, suggesting tailored treatments for PTEN-negative patients.

Key Points

This study investigates how different isoform-specific inhibitors of the PI3K pathway affect cancer cell viability, particularly in relation to PTEN status.
Examined effects of small-molecule inhibitors on class IA PI3Ks in cancer cells.
Conducted cell viability assays comparing responses across various PI3K isoform inhibitors.
Performed pharmacodynamic biomarker analysis in PTEN-negative tumor xenografts.
PTEN-negative cell lines showed less responsiveness (4-fold overall) to p110alpha/delta versus p110alpha/beta/delta inhibitors.
Combining a p110alpha/delta inhibitor with a p110beta inhibitor demonstrated comparable potency to the p110alpha/beta/delta inhibitor.
An inhibitor with insufficient potency against p110beta was less effective in inhibiting the PI3K pathway in PTEN-negative tumor xenografts.

Cite This Study

Edgar et al. (2010) studied this question.

synapsesocial.com/papers/6a1fa20600203a215af867f2 https://doi.org/10.1158/0008-5472.can-09-2525

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Isoform-Specific Phosphoinositide 3-Kinase Inhibitors Exert Distinct Effects in Solid Tumors

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Cite This Study

Isoform-Specific Phosphoinositide 3-Kinase Inhibitors Exert Distinct Effects in Solid Tumors

Discussion

Member takes

Implication

Key Points

Cite This Study

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