Key result
White ginseng extract cuts atheromatous plaque thickness ~50% without improving lipid levels.
Why the study?
Does white ginseng low-molecule extract improve blood lipid concentrations and atherosclerosis in rabbits with high cholesterol diet-induced hypercholesterolemia?
Does white ginseng low-molecule extract improve blood lipid concentrations and atherosclerosis in rabbits with high cholesterol diet-induced hypercholesterolemia?
Absolute Event Rate: 2238% vs 2090.6%
White ginseng phenolic compound-rich extracts may reduce the extent of atherosclerosis by improving oxidative stress, despite not lowering blood cholesterol.
Suggests antioxidant-mediated plaque reduction independent of lipids in rabbits; hypothesis-generating, leaves open human translation.
In this study, the effect of low-molecular weight white ginseng compounds on various biochemical indices, including blood lipid concentrations and antioxidant enzyme activities and morphological changes was investigated in rabbits with high cholesterol diet-induced hypercholesterolemia. The experimental animals were 16-week-old male New Zealand white rabbits divided into normal control diet, high cholesterol diet, and high cholesterol with 0.05% white ginseng low-molecule compound groups, treated for 4 weeks. Blood lipid concentrations were higher in the high cholesterol groups compared to the normal control group but were not improved by the white ginseng low-molecular weight compound. We note however that antioxidant enzyme activities and morphological changes of the aorta showed that white ginseng small compounds had a positive effect on hypercholesterolemia. Based on such results, low-molecular weight compounds rich in phenolic compounds in white ginseng can be said to be effective in part in improving hyperlipidemia and atherosclerosis induced by a high cholesterol diet among New Zealand white rabbits.
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Lee et al. (2013) studied High cholesterol diet-induced hypercholesterolemia (n=21). White ginseng low-molecule compound vs. High cholesterol diet was evaluated on Total cholesterol (mg/dL). White ginseng low-molecular weight compounds did not improve blood lipid concentrations but reduced atheromatous plaque thickness by about 50% and improved antioxidant enzyme activities.
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