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Objective: To explore the plaque biofilm microbiome associated with severe dental fluorosis (SF), and to describe its metagenome and metabolome. Methods: Sixteen plaque biofilm samples were collected from eight 6- to 15-year-old Thai children with SF and eight age-matched, caries-free and controls. Biofilms were analyzed using shotgun metagenomic sequencing, followed by bioinformatics evaluation. Results: activity, were upregulated in the SF group. Conclusion: provide mechanistic insights into its role as a candidate biomarker for fluorosis, warranting further investigation.
Ajrithirong et al. (Tue,) studied this question.