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CONTEXT: Psidium guajava L. (Myrtaceae) is widely used in traditional medicine for the treatment of various ailments including cardiovascular and gastrointestinal disorders. OBJECTIVES: The current study investigated the chemical composition and cardiovascular and gastrointestinal effects of the essential oil of P. guajava. MATERIALS AND METHODS: The chemical composition of the essential oil was investigated using gas chromatography-mass spectrometry (GC-MS) technique. The biological activity of the essential oil was tested on rabbit aorta and jejunum. All changes in isometric tension were recorded through a force transducer coupled with a bridge amplifier data acquisition system. RESULTS AND DISCUSSION: channel blockade. CONCLUSIONS: In summary, the data indicated the presence of seven different phytoconstituents in the essential oil of P. guajava and calcium channel blocking activity, which provides a pharmacological base to the traditional use of P. guajava in cardiovascular and gastrointestinal disorders. Further studies are suggested to explore the molecular nature of these effects.
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Rasheed et al. (2016) studied this question.
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