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November 1, 1975Acta Pharmacologica et Toxicologica

The Effect of a Calcium‐antagonistic Drug, Nifedipine, on the Mechanical and Electrical Activity of the Isolated Rat Atrium

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Key result

Nifedipine caused a dose-dependent decrease in spontaneous atrial rate, amplitude of contractions, and contractile force, and increased sinus node recovery time in isolated rat atria.

Why the study?

Does nifedipine alter the mechanical and electrical activity of isolated rat atria?

Population

Isolated rat atria

Design

Preclinical

Authors

HRHelge RefsumUniversity of OsloKLKnud LandmarkOslo University Hospital

Discussion

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Implication

Nifedipine effects in rat atria warrant no clinical extrapolation; leaves open calcium dependence of human sinoatrial node function.

Structured PICO

Does nifedipine alter the mechanical and electrical activity of isolated rat atria?

P
Population
Isolated rat atria investigated for mechanical and electrical behavior.
I
Intervention
Nifedipine (concentration range from 0.5 to 1000 μg/l)
O
Outcome
Mechanical and electrical behaviour (spontaneous atrial rate, amplitude of contractions, contractile force, threshold current, effective refractory period, and sinus node recovery time)surrogate

Nifedipine demonstrates that calcium ions are necessary for sino-atrial node pacemaker activity but not essential for maintaining atrial refractoriness and excitability in rat atria.

Cite This Study

Refsum et al. (1975) studied this question. Nifedipine was evaluated on Mechanical and electrical behavior (spontaneous atrial rate, amplitude of contractions, contractile force, effective refractory period, sinus node recovery time). Nifedipine caused a dose-dependent decrease in spontaneous atrial rate, amplitude of contractions, and contractile force, and increased sinus node recovery time in isolated rat atria.

synapsesocial.com/papers/6a1fac1d7f8f0ece98f87d99https://doi.org/10.1111/j.1600-0773.1975.tb00855.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Quinidine and Unidirectional Cation Fluxes in Atria1960 · 33 citations
  2. 2Calcium effect on performance of the heart1962 · 44 citations
  3. 3BASIC AND CLINICAL STUDIES ON BAY A 1040 WITH SPECIAL REFERENCE TO ITS INFLUENCE ON THE CORONARY, SYSTEMIC RESISTANCE AND CAPACITANCE BLOOD VESSELS1971 · 14 citations
  4. 4Effects of calcium, sodium and potassium ions on contractility of isolated atria and their responses to noradrenaline1969 · 28 citations
  5. 5A COMPARISON OF TESTS FOR ANTIFIBRILLATORY ACTION1961 · 56 citations