Key result
Prostaglandin-E2 functions in a negative feedback loop to limit IL-1beta-stimulated expression of PDGF-Ralpha and suppress PDGF-stimulated myofibroblast proliferation in rat lung cells.
Population
Cultured rat pulmonary myofibroblasts
Comparison
Interleukin-1 beta and/or Prostaglandin-E2, with… vs Untreated control cells
Design
Preclinical
Authors
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Hypothesis-generating for myofibroblast regulation in lung fibrosis; human studies needed before clinical relevance.
PGE2 functions in a negative feedback loop to limit IL-1beta-induced PDGF-Ralpha expression and suppress PDGF-stimulated myofibroblast proliferation in rat lung cells.
Boyle et al. (1999) studied Lung fibrogenesis. Prostaglandin-E2 and Interleukin-1 beta vs. Control was evaluated on PDGF-Ralpha expression and PDGF-stimulated mitogenesis. Prostaglandin-E2 functions in a negative feedback loop to limit IL-1beta-stimulated expression of PDGF-Ralpha and suppress PDGF-stimulated myofibroblast proliferation in rat lung cells.
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