March 1, 1980AJP Heart and Circulatory Physiology
Effects of current flow on pacemaker activity of the isolated kitten sinoatrial node
Population
isolated kitten sinoatrial (SA) nodal strips mounted in a sucrose gap
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Phase response curves may model sinus node responses to currents in animals; leaves open human translation.
Structured PICO
P
Population
isolated kitten sinoatrial (SA) nodal strips mounted in a sucrose gap
I
Intervention
Sustained stepwise applications of current and brief current pulses (hyperpolarizing or depolarizing)
O
Outcome
Pacemaker cycle length and phase shiftssurrogate
The study demonstrates that the behavior of the sinus nodal pacemaker in response to perturbing inputs can be predicted using a phase response curve.
Cite This Study
Jalife et al. (1980) studied this question.