December 1, 1985AJP Heart and Circulatory Physiology
Phase resetting and annihilation in a mathematical model of sinus node
Key result
Sinoatrial node phase-resetting and annihilation depend dynamically on slow inward and delayed outward currents.
Why the study?
A mathematical model was needed to better approximate the phase-resetting behavior and annihilation phenomena of sinoatrial pacemakers observed biologically.
Population
Mathematical model of primary sinoatrial pacemaker activity based on Hodgkin-Huxley type equations
Comparison
50-ms subthreshold current pulses vs baseline pacemaker activity
Design
Computer simulation with perturbation analysis
Authors
Discussion
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Member takes
Implication
Advances modeling of sinus node dynamics; leaves open relevance to human arrhythmias pending validation.
Structured PICO
P
Population
Mathematical model of primary sinoatrial pacemaker activity based on modifications of Hodgkin-Huxley type equations
I
Intervention
50-ms subthreshold current pulses (perturbation analysis)
O
Outcome
Phase-resetting behavior and annihilation characteristics
A mathematical model of the sinus node successfully simulated phase-resetting and annihilation behaviors, providing a basis for investigating complex arrhythmias.
Cite This Study
Reiner et al. (1985) studied Sinoatrial pacemaker activity. Subthreshold or electrotonic stimuli was evaluated on Phase-resetting behavior and annihilation. A mathematical model of the sinoatrial node demonstrated that phase-resetting behavior and annihilation depend on the dynamic interaction between slow inward and delayed rectifier outward currents.