Dynamic interactions and mutual synchronization of sinoatrial node pacemaker cells. A mathematical model.
Population
Computerized mathematical model of sinoatrial node pacemaker cells
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Hypothesis-generating for sinoatrial node dynamics; requires in vivo validation before informing research or practice.
Structured PICO
P
Population
Computerized mathematical model of sinoatrial node pacemaker cells
I
Intervention
Alteration of intrinsic frequency via bias hyperpolarizing current or slow inward current, and coupling cells through ohmic resistances
O
Outcome
Mutual interactions, entrainment, and synchronization patterns of coupled pacemaker cells
Mathematical modeling suggests that sinoatrial node synchronization occurs via mutual 'democratic' electrotonic interactions among individual pacemaker cells rather than being driven by a single dominant cell.
Cite This Study
Michaels et al. (1986) studied this question.