Effects of changes in excitability and intercellular coupling on synchronization in the rabbit sino‐atrial node.
Population
Biological preparations of thin strips of sino-atrial node from rabbit hearts, and computer simulations of…
Design
Preclinical
Authors
Discussion
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Implication
Animal data implicate gap junctions in sinus node entrainment; leaves open relevance to human pacemaker physiology or arrhythmias.
Structured PICO
P
Population
Biological preparations of thin strips of sino-atrial node from rabbit hearts, and computer simulations of the Hodgkin & Huxley type.
I
Intervention
Pharmacological manipulation of the middle segment ('gap') in a three-compartment bath using verapamil (2 microM), acetylcholine (10 microM), heptanol (3.5 mM), or hypertonic Tyrode solution (600 mosM), alongside corresponding mathematical simulations.
O
Outcome
Degree of synchronization and entrainment of spontaneous discharges between pace-maker centres.surrogate
Synchronization in the sinus node relies on mutual interactions and entrainment between cells, mediated through electrotonic propagation of current across low-resistance junctions.
Cite This Study
Delmar et al. (1986) studied this question.