Key result
Mathematical models of cardiac pacemaking highlight an ongoing debate between the membrane voltage-gated If current (M-clock) and intracellular calcium cycling (Ca2+-clock) as the primary driver of automaticity.
Design
Review
Authors
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Remains inconclusive on sinoatrial node drivers; leaves open primacy of M-clock versus Ca2+-clock, necessitating further research.
This review highlights the current state of debate and discrepancies among mathematical models of sinoatrial node electrophysiology, emphasizing the need for further research to understand cardiac pacemaking.
Li et al. (2013) conducted a review in Cardiac pacemaking function. Mathematical models of cardiac pacemaking was evaluated. Mathematical models of cardiac pacemaking highlight an ongoing debate between the membrane voltage-gated If current (M-clock) and intracellular calcium cycling (Ca2+-clock) as the primary driver of automaticity.
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