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August 1, 1982AJP Heart and Circulatory Physiology

A mathematical model of primary pacemaking cell in SA node of the heart

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Population

Mathematical model of the primary pacemaking cell (P-cell) of the sinoatrial (SA) node

Design

Preclinical

Authors

DBD. G. BristowJCJohn W. ClarkMarket Harborough Hospital

Discussion

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Overview

Supports computational sinoatrial node modeling; leaves open human translation and clinical relevance.

Structured PICO

P
Population
Mathematical model of the primary pacemaking cell (P-cell) of the sinoatrial (SA) node
I
Intervention
Modification of the McAllister-Noble-Tsien (MNT) model by deleting or inactivating selected inward- or outward-current channels and adjusting the range of voltage dependence
O
Outcome
Characterization of the free-running behavior of the primary pacemaker and its response to injected currents

A modified mathematical model successfully simulates the electrical activity and pacemaking behavior of sinoatrial node P-cells.

Cite This Study

Bristow et al. (1982) studied this question.

synapsesocial.com/papers/6a713b218031ec7bb1dcd668https://doi.org/10.1152/ajpheart.1982.243.2.h207
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A mathematical model of the vagally driven primary pacemaker1983 · 26 citations
  2. 2Dynamical description of sinoatrial node pacemaking: improved mathematical model for primary pacemaker cell2002 · 194 citations
  3. 3Mathematical models of cardiac pacemaking function2013 · 23 citations
  4. 4A model of sino-atrial node electrical activity based on a modification of the DiFrancesco-Noble (1984) equations1984 · 170 citations
  5. 5A mathematical model of a bullfrog cardiac pacemaker cell1990 · 60 citations