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January 1, 1983AJP Heart and Circulatory Physiology

A mathematical model of the vagally driven primary pacemaker

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Population

Mathematical model of the primary pacemaker cell (P-cell) in the sinoatrial (SA) node

Comparison

Addition of an acetylcholine-sensitive… vs Previous mathematical model without the…

Design

Preclinical

Authors

DBD. G. BristowJCJohn W. ClarkMarket Harborough Hospital

Discussion

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Overview

No immediate clinical implications; extends computational models of SA node responses to vagal input in animals.

Structured PICO

P
Population
Mathematical model of the primary pacemaker cell (P-cell) in the sinoatrial (SA) node
I
Intervention
Addition of an acetylcholine-sensitive 'muscarinic channel' to the membrane model
C
Comparator
Previous mathematical model without the muscarinic channel
O
Outcome
Simulation of free-running SA node cell and its responses to electrotonic and vagal stimulation

A mathematical model incorporating a muscarinic channel successfully simulates the electrical behavior and vagal responses of sinoatrial node pacemaker cells.

Cite This Study

Bristow et al. (1983) studied this question.

synapsesocial.com/papers/6a7f1f26f0b493274ef00dechttps://doi.org/10.1152/ajpheart.1983.244.1.h150
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A mathematical model of primary pacemaking cell in SA node of the heart1982 · 44 citations
  2. 2Functional and morphological organization of the rabbit sinus node.1980 · 367 citations
  3. 3EFFERENT CARDIAC VAGAL DISCHARGE OF THE DOG IN RESPONSE TO ELECTRICAL STIMULATION OF SENSORY NERVES1963 · 70 citations
  4. 4Synchronization of the Cardiac Pacemaker with Repetitive Stimulation of the Carotid Sinus Nerve in the Dog1972 · 24 citations
  5. 5Influence of Brief Vagal and Stellate Nerve Stimulation on Pacemaker Activity and Conduction within the Atrioventricular Conduction System of the Dog1973 · 142 citations